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. 2018 Dec 20;43(3):1193–1202. doi: 10.3892/ijmm.2018.4037

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Copyright: © Yang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Time course of HIF-1α and AQP4 protein expression for the control and NBO treatment groups. (A) Representative photographs of western blot analysis of HIF-1α and AQP4 expression in brain tissue during reperfusion at 2, 4, 6, 12, 24 and 48 h following the control and NBO treatment. β-tubulin was used as the loading control. (B) Quantification of HIF-1α expression. (C) Quantification of AQP4 expression. Values are presented as the mean ± standard deviation, n=3 per group. ^*P<0.05 vs. the sham group; ^#P<0.05 vs. the control group; ^&P<0.05 vs. the 60% NBO group. HIF-1α, hypoxia-inducible factor-1α; AQP4, aquaporin-4; NBO, normobaric oxygen therapy; MCAO, middle cerebral ischemic occlusion; I/R, ischemic/reperfusion.