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. 2019 Jan 10;43(3):1271–1280. doi: 10.3892/ijmm.2019.4059

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Metabolic disorders of HFD mice are reversed by SRT1720. The mice fed with the HFD became obese by 8 months of age compared with the control mice. (A) Body weight and (B) relative fat mass ratio of mice in the model group and vehicle group increased significantly, but only by ~20% in the mice treated with SRT1720. The model and vehicle mice developed hyperlipidemia as measured by (C) total plasma TG and (D) TC levels. Hyperlipidemia was reversed by SRT1720. (E) Images of the livers. (F) Consistent with an increase in plasma lipids, the HFD model mice exhibited significantly enlarged fatty livers at 8 months of age, which was reduced by SRT1720. The data are presented as the mean ± standard deviation from three independent experiments. ^*P<0.05 and **P<0.01. HDF, high-fat diet; TG, triglycerides; TC, total cholesterol.

Metabolic disorders of HFD mice are reversed by SRT1720. The mice fed with the HFD became obese by 8 months of age compared with the control mice. (A) Body weight and (B) relative fat mass ratio of mice in the model group and vehicle group increased significantly, but only by ~20% in the mice treated with SRT1720. The model and vehicle mice developed hyperlipidemia as measured by (C) total plasma TG and (D) TC levels. Hyperlipidemia was reversed by SRT1720. (E) Images of the livers. (F) Consistent with an increase in plasma lipids, the HFD model mice exhibited significantly enlarged fatty livers at 8 months of age, which was reduced by SRT1720. The data are presented as the mean ± standard deviation from three independent experiments. ^*P<0.05 and **P<0.01. HDF, high-fat diet; TG, triglycerides; TC, total cholesterol.