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. 2019 Jan 10;43(3):1271–1280. doi: 10.3892/ijmm.2019.4059

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Pathological and lipid metabolic changes of NAFLD mice are reversed by SRT1720. (A) Hepatic lipid content of the HFD model mice at 8 months of age was significantly increased compared with littermate controls, as separately measured using H&E and Oil Red O staining and (B) quantification of Oil Red O staining of liver sections (magnification, ×400). These data indicate typical pathology of liver steatosis. The content of extracted (C) liver triglycerides and (D) cholesterol from the HFD model were significantly increased compared with the control, but were reduced by SRT1720. The data are presented as the mean ± standard deviation from three independent experiments. ^*P<0.05 and ^**P<0.01. HDF, high-fat diet; NAFLD, non-alcoholic fatty liver disease; H&E, hematoxylin and eosin.

Pathological and lipid metabolic changes of NAFLD mice are reversed by SRT1720. (A) Hepatic lipid content of the HFD model mice at 8 months of age was significantly increased compared with littermate controls, as separately measured using H&E and Oil Red O staining and (B) quantification of Oil Red O staining of liver sections (magnification, ×400). These data indicate typical pathology of liver steatosis. The content of extracted (C) liver triglycerides and (D) cholesterol from the HFD model were significantly increased compared with the control, but were reduced by SRT1720. The data are presented as the mean ± standard deviation from three independent experiments. ^*P<0.05 and ^**P<0.01. HDF, high-fat diet; NAFLD, non-alcoholic fatty liver disease; H&E, hematoxylin and eosin.