Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jan 10;43(3):1271–1280. doi: 10.3892/ijmm.2019.4059

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PMC Copyright notice

SIRT1 regulates the acetylation level of QKI 5. (A) In the liver tissues of model mice, the acetylation level of QKI 5 increased, but this was reversed by SRT1720. (B) Increased acetylation of QKI 5 was induced by the inhibition of SIRT1 (niacinamide), but was decreased in hepatocytes treated with SRT1720. (C) Increasing acetylation of QKI 5 was induced by siRNA of SIRT1, but was decreased in hepatocytes treated with Ad-SIRT1. The results of protein interaction confirmed the interaction between (D) SIRT1 and (E) QKI 5, and its level in the SRT1720 group was increased compared with model mice. QKI 5, Quaking 5; SIRT1, Sirtuin 1; siRNA, small interfering RNA; Ad, adenovirus; IP, immunoprecipitation; WB, western blotting.