Skip to main content
. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Nat Genet. 2019 Jan 14;51(2):202–206. doi: 10.1038/s41588-018-0312-8

Table 1: Multivariable analysis of factors associated with overall survival.

HR 95% CI P value
Normalized Mutation Count
  Continuous 0.985 0.979–0.991 3.4×10−7
  Binary (Top 20%of each histology) 0.61 0.508–0.733 1.3×10−7
Cancer Type
  Melanoma (reference)
  NSCLC 2.08 1.61–2.68 1.9×10−8
  Not Melanoma/NSCLC 1.52 1.21–1.92 3.7×10−4
Age
0.995
0.990–1.004
0.07
Drug Class
  PD-1/PD-L1 (reference)
  CTLA4 1.18 0.846–1.66 0.32
  Combo 0.67 0.534–0.844 6.6×10−4
Year of ICI start
2.3X10−8

ICI-Immune Checkpoint Inhibitor

Cox proportional hazards multivariable analysis of overall survival in 1662 patients treated with ICI demonstrating the hazard ratios for individual covariates.