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. Author manuscript; available in PMC: 2019 Feb 6.
Published in final edited form as: Curr Top Membr. 2012;69:137–161. doi: 10.1016/B978-0-12-394390-3.00006-9

Table 1.

Predicted phosphorylation sites in ATP7B

Phosphosites/phosphopeptides Type of phosphorylation Effect of mutation Ref.
[Ser 478 (N-terminal), Ser 481(N-terminal), Ser 1121 (NBD), Ser 1453 (C-terminal)]h Copper responsive Quadruple S > A mutant is not trafficking in response to copper. (Pilankatta et al., 2009, 2011)
(340 SSSSHSPGSPPR)N,h Basal/constitutive S340/341 mutants are localized in vesicles. (Bartee et al., 2009)
(270 SCVLNIEENIGQLLGVQSIQVSLENK)N,h
 (352 NQVQGTCSTTL)N,h
 (407 VISPEELR)N,h
 (415 AIEDMGFEASVVSESCSTNPLGNHSAGN)N,h
 (439 HSAGNSMVQTTDGTPTSVQEVAPHTGR)N,h
 (444 SMVQTTDGTPTSVQEVAPHTGR)N,h
 (496 GMTCASCVSNIER)N,h
 (512 EAGVLSVLVALMAGK)N,h
 (589 TNGITYASVALATSK)N,h
 (595 ASVALATSK)N,h 		Basal/constitutive ND (Bartee et al., 2009)
(140 AAS142WPSR)N,m Basal/constitutive ND (Huttlin et al., 2010)
(1389 MKPLS1393AS1395QVS1398VHIGMDDR)*,C,m Basal/constitutive ND (Huttlin et al., 2010)
(1389 MKPLSAS1395QVSVHI)C,m Insulin dependent ND (putative kinase motif: NEK6) (Monetti et al., 2011)
(458 GLLTHQGPGYLSDSPPS474PGGTASQ)N,r Insulin dependent ND (Fedjaev et al., 2012)
(128 AAS130WPSR)N,r Basal/constitutive ND (Lundby et al., 2012)
(323 VS324LPDGLEK)N,r Basal/constitutive ND (Lundby et al., 2012)
(431 VSSGNSVPQAVGDS444PGS447VQNMASDTR)*, N,r Basal/constitutive ND (Lundby et al., 2012)
(457 GLLTHQGPGYLS468DS470PPS473PGGT477ASQK)*, N,r Basal/constitutive ND (Lundby et al., 2012)
(1381 PLS1383AS1385QVS1388VHVGMDDR)*, C,r Basal/constitutive ND (Lundby et al., 2012)
(1439 WSLLLS1444DR)*, C,r Basal/constitutive ND (Lundby et al., 2012)

Species: m-mouse; r-rat; h-human; N-N-terminal; C-C-terminal; ND: not determined.

*

The identified phosphopeptide has different phosphorylated residue combinations identified by MS, and different phospho-occupancy.