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. 2019 Feb 6;5(2):eaav2309. doi: 10.1126/sciadv.aav2309

Fig. 1. Subclinical endotoxemia exacerbates atherosclerotic pathogenesis.

Fig. 1

ApoE−/− mice were administrated with PBS or superlow-dose LPS, together with HFD for 4 weeks. (A) Representative images of H&E-stained atherosclerotic lesions and quantification of plaque size demonstrated as the percentage of lesion area within aortic root area. Scale bars, 300 μm. (B) Representative images of Oil Red O–stained atherosclerotic plaques and quantification of lipid deposition within lesion area. Scale bars, 300 μm. (C) Representative images of Picrosirius red–stained atherosclerotic plaques and quantification of collagen content within lesion area. Scale bars, 100 μm. (D) Determination of circulating MMP9, LTB4, and TGFβ levels by enzyme-linked immunosorbent assay (ELISA). Data are representative of two independent experiments, and error bars represent means ± SEM. *P < 0.05, **P < 0.01, and ***P < 0.001; Student’s t test (n = 5 for each group).