Fig. 2. Subclinical endotoxin primes neutrophils into a proinflammatory state in atherosclerotic mice.

ApoE^−/− mice were administrated with PBS or superlow-dose LPS, together with HFD for 4 weeks. The surface phenotypes of Ly6G⁺ neutrophils in the peripheral blood (A), spleen (B), and BM (C) were analyzed with flow cytometry. Data are representative of two independent experiments, and error bars represent means ± SEM. *P < 0.05, **P < 0.01, and ***P < 0.001, Student’s t test (n = 5 for each group). ns, not significant.