Table 3. GLM-adjusted protein groups significantly associated with Aβ SUVR in cognitively unimpaired participants stratified by Aβ+/− classification after multiple testing correction.

Protein groups were also associated with Aβ SUVR with an adjustment for APOE genotype. All protein groups that are nominally associated with Aβ in cognitively unimpaired (P > 0.05) are shown in table S1.

UniProt ID	Protein group description	Aβ+ group					Adjusted for APOE ε4 status
			t	Mean difference	P value	Q	t	Mean difference	P value	Q value
P05067	APP	↑	−5.651	−0.290	4.57 × 10−08	2.08x10−05	−4.686	−0.241	4.71 × 10−06	0.001
Q9H2A3	NGN2	↑	−5.556	−0.319	7.43 × 10−08	2.08x10−05	−4.787	−0.276	2.99 × 10−06	0.001
P07196	NfL	↑	−4.639	−0.229	5.80 × 10−06	0.001	−3.716	−0.184	2.53 × 10−04	0.047
O95704	APBB3	↑	−4.389	−0.274	1.71 × 10−05	0.002	−3.374	−0.210	0.001	ns
Q13127	REST	↓	3.570	0.142	4.33 × 10−04	0.048	3.385	0.135	0.001	ns