Table 4. GLM-adjusted protein groups significantly associated with Aβ SUVR in all subjects stratified by Aβ+/− classification after Benjamini-Hochberg multiple testing corrections.
Protein groups were also associated with Aβ SUVR with an adjustment for APOE genotype. All protein groups that are nominally associated with Aβ (P > 0.05) are shown in table S2 (A and B).
| UniProt ID |
Protein group description |
Aβ+ group | Adjusted for APOE ε4 status | |||||||
| t | Mean difference | P value | Q | t | Mean difference | P value | Q value | |||
| P05067 | Aβ A4 protein | ↑ | −6.419 | −0.279 | 5.79 × 10−10 | 3.24 × 10−07 | −5.019 | −0.220 | 9.22 × 10−07 | 0.001 |
| Q9H2A3 | NGN2 | ↑ | −5.702 | −0.283 | 2.98 × 10−08 | 8.34 × 10−06 | −4.624 | −0.231 | 5.75 × 10−06 | 0.002 |
| P07196 | NfL | ↑ | −5.258 | −0.219 | 2.88 × 10−07 | 5.38 × 10−05 | −3.928 | −0.164 | 1.08 × 10−04 | 0.015 |
| O95704 | APBB3 | ↑ | −5.189 | −0.272 | 4.05 × 10−07 | 5.67 × 10−05 | −3.710 | −0.194 | 2.49 × 10−04 | 0.028 |
| Q13127 | REST | ↓ | 4.247 | 0.143 | 2.94 × 10−05 | 3.29 × 10−03 | 3.984 | 0.135 | 8.64 × 10−05 | 0.015 |
| P81274 | GPSM2 | ↓ | 4.016 | 0.124 | 7.61 × 10−05 | 0.007 | 3.564 | 0.111 | 4.28 × 10−04 | 0.040 |
| Q13103 | SPP2 | ↓ | 3.833 | 0.108 | 1.56 × 10−04 | 0.013 | 3.310 | 0.094 | 0.001 | 0.084 |
| Q8IVF4 | DNAH10 (axonemal) |
↑ | −3.548 | −0.090 | 4.54 × 10−04 | 0.032 | −3.165 | −0.081 | 0.002 | 0.120 |