Table 5. Feature list for multianalyte classifier predicting elevated Aβ burden in cognitively unimpaired cohort.
The classifier was training in the AIBL cohort (n = 144), achieving a testing AUC of 0.891 in the KARVIAH cohort (n = 94). GPCR, G protein–coupled receptor; sens, sensitivity; spec, specificity.
|
Feature no. |
Cognitively unimpaired classifier for Aβ burden (Testing AUC = 0.891, sens = 0.78, spec = 0.77, NPV = 0.68, PPV = 0.85) |
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| UniProt ID |
Feature description |
Tryptic amino acid peptide sequences contributing to protein scores | |
| 1 | P00734 | Prothrombin | 87–94, 98–116, 125–133, 178–198, 199–224, 217–224, 225–243, 248–263, 315–327, 328–344, 345–363, 354–363, 441–447, 447–452, 467–468, 518–537, 544–560, and 560–575 |
| 2 | Q8IZF3 | Adhesion GPCR F4 |
100–107, 315–328, 657–689, and 673–698 |
| 3 | P05067 | Aβ A4 protein | 677–687 and 688–699 |
| 4 | Q9H2A3 | NGN2 | 114–120 |
| 5 | n/a | APOE ε4 count | n/a |
| 6 | Q8IVF4 | DNAH10 (axonemal) |
207–223, 528–540, 879–915, 1133–1148, 1524–1528, 1870–1927, 2404–2436, 2906–2941, 2923–2945, and 4100–4139 |
| 7 | Q13127 | REST | 353–369, 727–742, and 882–896 |
| 8 | P07196 | NfL | 137–144, 154–164, 318–331, and 447–462 |
| 9 | P51812 | RPS6KA3 | 80–100, 109–132, 193–216, 226–242, 274–282, 508–525, and 570–591 |
| 10 | P81274 | GPSM2 | 267–278, 318–347, and 422–433 |
| 11 | B1AJZ9 | FHAD1 | 861–868, 876–887, 897–905, 931–942, 1030–1052, 1059–1070, and 1104–1139 |
| 12 | n/a | Age of participant |
n/a |