Table 6. Feature list for multianalyte classifier predicting elevated Aβ burden in a mixed diagnosis cohort.
The classifier was training in the AIBL cohort (n = 169), achieving a testing AUC of 0.905 in the KARVIAH cohort (n = 94).
| Feature no. |
Mixed diagnosis classifier for Aβ burden (Testing AUC = 0.904, sens = 0.81, spec = 0.80, NPV = 0.72, PPV = 0.87) |
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| UniProt ID |
Feature description |
Tryptic amino acid peptide sequences contributing to protein scores | |
| 1 | n/a | APOE ε4 count* | n/a |
| 2 | P05067 | Aβ A4 protein* | 677–687 and 688–699 |
| 3 | P07196 | NfL* | 137–144, 154–164, 318–331, and 447–462 |
| 4 | Q9H2A3 | NGN2* | 114-120 |
| 5 | Q8IVF4 | DNAH10 (axonemal)* |
207–223, 528–540, 879–915, 1133–1148, 1524–1528, 1870–1927, 2404–2436, 2906–2941, 2923–2945, and 4100–4139 |
| 6 | Q13127 | REST* | 353–369, 727–742, and 882–896 |
| 7 | O95704 | APBB3 | 155–175 and 414–430 |
| 8 | P81274 | GPSM2* | 267–278, 318–347, and 422–433 |
| 9 | P00734 | Prothrombin* | 87-94, 98–116, 125–133, 178–198, 199–224, 217–224, 225–243, 248–263, 315–327, 328–344, 345–363, 354–363, 441–447, 447–452, 467–468, 518–537, 544–560, and 560–575 |
| 10 | B1AJZ9 | FHAD1* | 861–868, 876–887, 897–905, 931–942, 1030–1052, 1059–1070, and 1104–1139 |
*Proteins also included in the classifier for predicting Aβ in the cognitively unimpaired individuals.