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. Author manuscript; available in PMC: 2019 Nov 10.
Published in final edited form as: J Control Release. 2018 Sep 24;289:114–124. doi: 10.1016/j.jconrel.2018.09.020

Figure 4.

Figure 4.

Anti-M2e (A) total IgG, (B) IgG1, and (C) IgG2a antibody titers of mice vaccinated on Day 0 and 21 with phosphate-buffered saline (PBS), soluble M2e (solM2e), solM2e MF59-like AddaVax (solM2e + squalene), solM2e + cGAMP-loaded microparticles (cGAMP MPs (60%)), M2e-loaded MPs (M2e MPs (20, 40, or 60%)) + cGAMP MPs (60%), or MPs containing both M2e and cGAMP (M2e/cGAMP MPs (60%)) (n = 5). All MPs were composed of acetalated dextran (Ace-DEX), and percentages indicate Ace-DEX MP relative cyclic acetal coverages. MP dose was adjusted to administer 10 μg M2e and/or 1 μg cGAMP.