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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Hum Pathol. 2018 Aug 30;83:124–132. doi: 10.1016/j.humpath.2018.08.019

Table 1:

Concordance Among Methods of MYC Immunohistochemical Stain Evaluation1

Concordance Cohen Kappa Statistic Agreement2
Original IHC interpretation to manual retrospective review (n=69) 80% 0.588 Good
Original IHC interpretation to retrospective review by digital image analysis (n=78) 81% 0.616 Good
Retrospective manual review to retrospective review by digital image analysis (n=75) 80% 0.606 Good
Core Biopsy Only
Original IHC interpretation to manual retrospective review (n=23) 87% 0.738 Good
Original IHC interpretation to retrospective review by digital image analysis (n=30) 80% 0.598 Good
Retrospective manual review to retrospective review by digital image analysis (n=24) 96% 0.915 Excellent
Excisional Biopsy Only
Original IHC interpretation to manual retrospective review (n=46) 76% 0.513 Good
Original IHC interpretation to retrospective review by digital image analysis (n=48) 81% 0.626 Good
Retrospective manual review to retrospective review by digital image analysis (n=51) 73% 0.474 Good
1

Concordance evaluated using any nuclear staining by manual retrospective review and 1+ through 3+ nuclear positivity by digital image analysis to determine percent myc positivity, and using a cut-off of ≥ 40% as positive.

2

As defined by Le (10).