Table 2.
MYC immunohistochemical staining versus MYC gene rearrangement status (Excisional biopsy specimens only)
|
MYC
gene rearrangement (N=9)1 |
No MYC gene rearrangement (N=28)1 |
P- value |
|
|---|---|---|---|
| Myc immunostain percent positivity by: | Median (25%, 75%) | Median (25%, 75%) | |
| Digital image analysis (1++−3+) | 65.6 (63.1, 80.9) | 29.5 (14.7, 43.4) | 0.001 |
| Digital image analysis (2++−3+) | 30.7 (19.3, 51.3) | 14.0 (5.3, 23.8) | 0.02 |
| Manual retrospective (any staining) | 90.0(81.9, 91.0) | 48.6 (23.0, 63.9) | 0.0005 |
| Manual retrospective (bright staining) | 67.5 (38.1, 85.0) | 25.0 (9.0, 42.8) | 0.009 |
| Original pathologist’s interpretation of myc staining: | Number (percentage) | Number (percentage) | 0.002 |
| Positive | 9 (100) | 9 (32.1) | |
| Negative | 0 (0.0) | 15 (53.6) | |
| Equivocal | 0 (0.0) | 4 (14.3) |
1
Overall N may vary by variable.