Figure 3.

Trends in oral antibiotic use in the autism spectrum disorder (ASD) cohort and general population without an ASD diagnosis (POP) cohort, and in their subcohorts describing children with and without a gastrointestinal (GI) symptom diagnosed during the late enrollment period (+GI and −no GI subcohorts, respectively): (a) relative frequency distributions for the number of oral antibiotic fills during the early enrollment period for members of each GI subcohort and the primary cohorts; (b) proportion of the members in each cohort and GI subcohort that had an oral antibiotic fill during each three-month interval of the total five-year enrollment period. Each point represents the total proportion of individuals during the indicated three-month period.