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. 2019 Jan 28;103(2):291–298. doi: 10.1097/TP.0000000000002384

FIGURE 2.

FIGURE 2

Effects of the transplanted induced pluripotent SC-derived cardiomycocytes (iPS-CM), skeletal myoblast (SM), and mesnchymal stem cell sheets on global cardiac function. A–D, Cardiac MRI results (infarcted porcine without cell therapy (n = 8); infarcted porcine receiving iPS-CM sheets (n = 7); infarcted porcine receiving SM sheets (n = 7); infarcted porcine receiving MSC sheets (n = 7). A, left ventricle ejection fraction (LVEF) post infarction; there were no differences in the baseline value among the groups after 1 month. NS, no significant difference. All cell therapy groups showed a similar increase in LVEF 2 months post cell therapy (#P < 0.05). The LVEF was higher in the hearts with cell therapy when compared with those without cell therapy after 2 months (*P < 0.05). B, LV end diastolic volume was increased in each group relative to the baseline value after 2 months (#P < 0.05). C, LV end systolic volume in the hearts receiving iPS-CM was lower than that in other cell types at 2 months (*P < 0.05); however, it was increased in the hearts of control animals (#P < 0.05). D, The iPS-CM therapy alleviated global wall stress when compared with that in the animals transplanted with other cell types and the control group (*P < 0.05).