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. 2019 Jan 28;103(2):291–298. doi: 10.1097/TP.0000000000002384

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Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Induced pluripotent SC-derived cardiomycocytes (iPS-CM) therapy reduces CM apoptosis. Apoptotic CMs were identified in sections from the IZ in the hearts from animals in the (A) induced pluripotent SC-derived cardiomycocytes (iPS-CM), (B) skeletal myoblast (SM), (C) mesnchymal stem cell, and (D) control groups by fluorescence immunolabeling of ssDNA (red). CMs were visualized by fluorescence immunolabeling cardiac troponin T (cTnT) (green); nuclei were counterstained with 4′,6-diamidino-2-phenylindole (DAPI) (blue). (i-iv) Representative ssDNA+ myocytes under high magnification in figure insets; denoted by arrowheads. E, CM apoptosis was quantified as the percent of cardiac troponin T (cTnT)-positive cells that were also positive for ssDNA (*P < 0.05). Scale bar, 50 μm.