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. 2018 Oct 29;4(2):310–320. doi: 10.1016/j.ekir.2018.10.021

Table 2.

CPI-613 dose and infusion rate

CPI-613 dose per time interval n mg m/kg mg/m2
First dose 33 3975.0 (1842.2), 4300.0 50.6 (21.5), 58.4 2071.1 (880.9), 2311.6
First 5 doses 27 19,013.0 (9622.8), 21,250.0 240.2 (109.1), 291.1 9811.6 (4549.2), 11,494.3
First 4 weeks 26 26,107.6 (12,887.4), 27400.0 326.6 (147.8), 364.6 13,370.8 (6107.7), 14,845.4
Weeks 5 through 15 21 49,550.0 (28,354.9), 49550.0 538.5 (306.6), 537.7 21,770.0 (11,888.9), 22,988.5
Weeks 16 through 24 9 44,988.9 (30,160.3), 29000.0 573.9 (456.1), 385.7 23,427.8 (17,804.5), 15,025.9
Weeks 25 through 36 2 101,250.0 (8273.2), 101250.0 1442.9 (230.8), 1442.9 57,307.3 (6506.6), 57,307.3
Weeks 37 through 48 2 83,000.0 (12,445.1), 83000.0 1186.0 (269.6), 1186.0 47,029.0 (8534.1), 47,029.0
Weeks 49 through 72 1 202,500.0 3036.8 117,052.0
Weeks 73 through 96 1 76,800.0 1151.7 44,393.1
CPI-613 infusion rate n mg × min−1 m/kg × min−1 mg/m2 × min−1
First dose 33 33.1 (15.4), 35.8 0.4 (0.2), 0.5 17.2 (8.0), 19.2
First 5 doses 27 158.4 (80.2), 177.1 2.0 (0.9), 2.4 81.8 (37.9), 95.8

Data presented as mean (SD), median. n, number of patients.