Table 3.
Laboratory parameters by time interval following initiation of CPI-613 chemotherapy
| Parameter | Weeks 1–4 |
Weeks 5–12 |
Weeks 13–24 |
Weeks 25–36 |
Weeks 37–48 |
Weeks 49–72 |
Weeks 73–96 |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | Mean (SD), median | n | Mean (SD), median | n | Mean (SD), median | n | Mean (SD), median | n | Mean (SD), median | n | Mean (SD), median | n | Mean (SD), median | |
| Creatinine, serum (mg/dl)a | 33 | 1.3 (1.2), 0.9 | 27 | 1.2 (0.8), 1.0 | 17 | 1.3 (1.0), 1.0 | 7 | 0.9 (0.0), 0.4 | 5 | 0.9 (0.1), 1.0 | 5 | 0.9 (0.2), 0.9 | 4 | 0.8 (0.1), 0.8 |
| BUN (mg/dl)b | 33 | 20.8 (13.0), 16.0 | 27 | 24.5 (18.2), 22.0 | 17 | 21.1 (18.7), 18.0 | 7 | 18.0 (4.6), 17.0 | 5 | 18.0 (3.2), 20.0 | 5 | 15.8 (4.8), 17.0 | 4 | 16.5 (3.0), 17.0 |
| Hemoglobin (g/dl)c | 33 | 9.7 (2.0), 10.1 | 27 | 9.2 (2.1), 9.3 | 17 | 9.6 (2.3), 8.1 | 7 | 8.4 (2.2), 7.6 | 5 | 8.2 (2.1), 7.9 | 5 | 7.6 (1.6), 7.2 | 4 | 6.7 (0.8), 6.8 |
| Platelets (× 103/μl)c | 33 | 151.6 (112.3), 142.0 | 27 | 133.1 (111.3), 124.0 | 17 | 119.2 (85.2), 117.0 | 7 | 80.2 (93.4), 50.0 | 5 | 49.0 (56.9), 15.0 | 5 | 50.6 (50.3), 28.0 | 4 | 28.0 (42.8), 9.0 |
| Potassium, serum (mEq/l)a | 33 | 4.3 (0.6), 4.3 | 27 | 4.5 (0.5), 4.4 | 17 | 4.5 (0.4), 4.5 | 7 | 4.3 (0.3), 4.3 | 5 | 4.2 (0.1), 4.3 | 5 | 4.5 (0.1), 4.6 | 4 | 4.2 (0.2), 4.3 |
| Bicarbonate, serum (mEq/l)a | 33 | 28.2 (2.3), 28.0 | 27 | 28.6 (2.1), 28.0 | 17 | 27.8 (3.6), 28.0 | 7 | 29.0 (3.5), 29.5 | 5 | 29.0 (2.8), 28.0 | 5 | 28.6 (2.8), 28.0 | 4 | 28.0 (2.4), 27.5 |
| Magnesium, serum (mg/dl)a | 31 | 2.0 (0.2), 2.0 | 24 | 2.0 (0.1), 2.0 | 12 | 2.0 (0.2), 2.0 | 6 | 2.1 (0.2), 2.1 | 4 | 1.9 (0.2), 1.9 | 4 | 2.1 (0.05), 2.1 | 3 | 2.0 (0.1), 2.1 |
| Phosphorus, serum (mg/dl)a | 30 | 3.7 (0.8), 3.6 | 23 | 3.9 (0.7), 3.9 | 11 | 4.1 (1.2), 3.6 | 3 | 3.9 (0.6), 3.7 | 3 | 4.0 (0.2), 4.0 | 2 | 4.4 (0.2), 4.4 | 1 | 4.6 (0.1), 4.6 |
| Lactate dehydrogenase, serum (IU/l)a | 21 | 498.9 (1267.2), 201.5 | 14 | 222.0 (109.2), 188.5 | 8 | 273.1 (149.1), 235.5 | 5 | 344.8. (289.6), 222.0 | 4 | 207.5 (77.1), 188.5 | 2 | 192.0 (14.1), 192.0 | 4 | 286.7 (210.5), 213.0 |
| Uric acid, serum (mg/dl)a | 3 | 8.0 (3.4), 6.9 | 4 | 5.1 (0.5), 5.2 | 1 | 3.9 (1.0), 4.5 | 3 | 4.6 (0.4), 4.4 | 2 | 4.2 (0.7), 4.3 | 1 | 4.9 | 3 | 5.2 (0.2), 5.1 |
BUN, blood urea nitrogen; n, number of patients.
Data presented as mean (SD), median. Values listed based on apeak measurements, bconcomitant level at peak serum creatinine, and cnadir measurements.