Table 5.

Association among baseline demographics, laboratory parameters, CPI-613 dose, and infusion rate with AKI

Parameter	Hazard ratio	95% confidence interval	P
Age at first CPI infusion (per 5 years)	2.01	1.06–3.79	0.03
Female	2.42	0.40–14.5	0.33
Black	2.06	0.23–18.6	0.52
Diabetes mellitus	1.03	0.17–6.22	0.97
Serum creatinine (per 0.1 unit)	0.83	0.54–1.28	0.41
Blood urea nitrogen (per 1 unit)	0.97	0.81–1.16	0.74
Hemoglobin (per 1 unit)	0.93	0.71–1.23	0.62
Lactate dehydrogenase (per 10 units)	0.95	0.75–1.20	0.64
First dose CPI-613, mg (per 1000 mg)	0.81	0.51–1.28	0.37
First dose CPI-613, mg/kg (per 10 units)	0.91	0.62–1.33	0.62
First dose CPI-613, mg/m2 (per 100 units)	0.97	0.88–1.06	0.49
First dose CPI-613, mg/body mass index (per 10 units)	0.96	0.84–1.09	0.50
Infusion rate first CPI-613 dose, mg/kg × min−1 (per 0.1 units)	1.10	0.80–1.51	0.56
Infusion rate first CPI-613 dose, mg/m2 × min−1 (per 5 units)	1.27	0.64–2.51	0.49
Cumulative CPI-613 dose, mg (per 1000 mg)	0.99	0.97–1.01	0.41
Cumulative CPI-613 dose, mg/kg (per 10 units)	0.99	0.98–1.01	0.47
Cumulative CPI-613 dose, mg/m2 (per 100 units)	0.998	0.994–1.003	0.43
Cumulative CPI-613 dose, mg/body mass index (per 10 units)	0.998	0.991–1.004	0.46