Figure 6.

HLA Ligandome Analysis Revealed Increased Peptide Presentation upon MeV-Containing Combinatorial Treatments

(A) Graph enumerating peptides and source proteins isolated from LNZ308 cells after individual treatments using HLA ligandomics, with CT-VT showing maximal presentation of peptides with 1,430 peptides, followed by CT-VT-RT with 1,222 peptides post-normalization. (B) Semiquantitative volcano plot analysis visualizing modulations in HLA ligands presented on LNZ308 cells upon different treatment regimens. Each dot represents an HLA ligand, with log2-fold changes in HLA ligand number indicated on the x axis and the respective Benjamini-Hochberg-corrected significance levels on the y axis. Significantly upregulated or downregulated HLA ligands (>4-fold difference in number; p < 0.01) are highlighted in red and blue, respectively. The significantly modulated HLA ligand percentages are mentioned in the quadrants.