Table 4.

Diagnostic accuracy of important amino acids for nephrosclerosis and its clinical criteria

	PC 1	Homocysteine	Glutamate	Histidine	Kynurenine	Leucine	Phenylalanine	Serine	Tyrosine
Nephrosclerosis	0.63 (0.51–0.75)	0.65 (0.53–0.77)	0.63 (0.50–0.75)	0.59 (0.47–0.72)	0.62 (0.50–0.74)	0.61 (0.48–0.73)	0.62 (0.49–0.74)	0.61 (0.48–0.75)	0.64 (0.51–0.0.77)
Hypertension	0.63 (0.50–0.77)	0.65 (0.52–0.78)	0.63 (0.51–0.76)	0.58 (0.45–0.72)	0.61 (0.48–0.74)	0.63 (0.51–0.75)	0.60 (0.48–0.73)	0.60 (0.47–0.74)	0.63 (0.50–0.76)
eGFR	0.50 (0.37–0.62)	0.51 (0.39–0.63)	0.52 (0.40–0.64)	0.58 (0.46–0.69)	0.50 (0.38–0.62)	0.54 (0.42–0.67)	0.53 (0.42–0.65)	0.56 (0.44–0.68)	0.55 (0.42–0.66)
Proteinuria	0.55 (0.36–0.74)	0.55 (0.42–0.76)	0.52 (0.35–0.69)	0.60 (0.30–0.90)	0.54 (0.29–0.79)	0.50 (0.27–0.72)	0.59 (0.44–0.75)	0.51 (0.28–0.75)	0.61 (0.47–0.76)
Hematuria	0.60 (0.41–0.77)	0.56 (0.37–0.76)	0.62 (0.40–0.84)	0.52 (0.32–0.72)	0.58 (0.39–0.79)	0.51 (0.30–0.72)	0.62 (0.45–0.79)	0.68 (0.49–0.86)	0.62 (0.45–0.80)

Note: Principal Component (PC) 1 includes information from all amino acids reduced into 1 variable describing the variation in the dataset irrespective of diagnostic group. The specific amino acids displayed are the top 5 from Table 2 (highest significance for distribution differences) and the top 5 from Figure 1 (highest variable importance in projection score in partial least squares discriminant analysis). Data are area under the receiver operating characteristic curves (95% confidence interval). Negative associations giving values below 0.5, which is the line of indifference, are transformed (1 − x) for ease of comparison. Significant data are highlighted in bold.

eGFR, estimated glomerular filtration rate.