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. 2019 Jan 31;10:7. doi: 10.3389/fgene.2019.00007

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Copyright © 2019 Klein, Tremmel, Winter, Fehr, Battke, Scheurenbrand, Schaeffeler, Biskup, Schwab and Zanger.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Study overview. (A) Schematic overview of the workflow for the ADME NGS panel sequencing. cov, coverage; NAF, novel allele frequency; HWE, Hardy–Weinberg equilibrium; MAF, minor allele frequency; eQTL, expression quantitative trait loci. (B) Composition of ADME NGS target genes displayed in % of total number (n = 340). Number of target genes within a family is given in brackets. Sum of target size is given in kbp. Major functional classes were defined as Phase 1, phase 1 enzymes; CYP/modifiers, cytochrome P450 and modifying enzymes; Phase 2, phase 2 enzymes; ABC, ABC transporters; SLC/SLCO, SLC/SLCO transporters and ion channels; NR/TR, nuclear receptors and transcriptional regulators; Others, other genes. For further details see Supplementary Table S1. (C) Ideogram of the genes included in ADME NGS panel. Target genes (n = 340) are denoted by red arrows besides chromosomes (GRCh37).