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. 2019 Jan 31;10:7. doi: 10.3389/fgene.2019.00007

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Copyright © 2019 Klein, Tremmel, Winter, Fehr, Battke, Scheurenbrand, Schaeffeler, Biskup, Schwab and Zanger.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cis-eQTL analysis of common variants. Top cis-associations of common variants to mRNA expression. Manhattan plot presenting top results from multivariate cis association analysis between mRNA expression and common variants (MAF ≥ 2%) investigated for the corresponding gene. Displayed are minimal p-values (min. p) from four genetic models (codominant, dominant, recessive, and additive). In total, n = 3,241 common variants in n = 295 genes were analyzed. Only genes with at least one significant cis-association after Bonferroni correction (p < 0.05/3,241 = 1.54E-05; dotted line) are shown with all minimal p-values. The significant p-values are presented in Table 2.