Table 2.
Gene | Varianta | dbSNP151 | Functional class | Minimal p-valueb |
---|---|---|---|---|
ABCA5 | 17_67242245_G_A | rs12942867 | 3′UTR | 1.20E-08 A |
17_67242551_AG_A | rs321469 | 3′UTR | 1.20E-08 A | |
17_67242756_G_A | rs1990248 | 3′UTR | 9.00E-08 A | |
17_67243289_A_T | rs15886 | 3′UTR | 1.20E-08 A | |
17_67260926_A_G | rs12449649 | Synonymous | 1.00E-08 A | |
17_67267317_T_C | rs557491 | Missense | 1.10E-07 A | |
17_67282332_T_C | rs1550828 | Intron | 1.00E-08 A | |
ABCC11 | 16_48250011_G_A | rs11863233 | Intron | 6.90E-11 A |
16_48250026_G_T | rs11863236 | Missense | 6.90E-11 A | |
16_48250218_T_C | rs28654935 | Intron | 6.90E-11 A | |
16_48256602_T_C | rs16945974 | Synonymous | 6.90E-11 A | |
16_48265777_C_T | rs16945988 | Missense | 6.90E-11 A | |
16_48269120_TAGAGATGCAA_T | rs398088092 | Upstream | 3.20E-10 C | |
16_48269140_AAGAGATGCAA_A | Upstream | 1.80E-09 A | ||
16_48269561_A_G | rs10521167 | Upstream | 6.90E-11 A | |
16_48269918_T_C | rs16946006 | Upstream | 6.90E-11 A | |
16_48270429_C_T | rs9926206 | Upstream | 6.90E-11 A | |
16_48270508_T_C | rs9934833 | Upstream | 6.90E-11 A | |
16_48270574_A_G | rs9932328 | Upstream | 6.90E-11 A | |
AOC1 | 7_150553605_C_T | rs10156191 | Missense | 8.50E-06 A |
7_150555915_A_G | rs10893 | Synonymous | 3.40E-08 R | |
7_150557622_G_A | rs12179 | Synonymous | 6.50E-09 R | |
7_150557665_C_G | rs1049793 | Missense | 6.50E-09 R | |
7_150558366_C_T | rs12539 | 3′UTR | 6.30E-09 D | |
ALDH6A1 | 14_74527190_A_G | rs8204 | 3′UTR | 1.40E-05 C |
ARNT | 1_150783934_G_GCACA | rs71580328 | 3′UTR | 1.90E-10 D |
1_150783934_G_GCACACA | rs71580328 | 3′UTR | 5.80E-10 C | |
1_150783985_T_C | rs11552229 | 3′UTR | 3.10E-12 A | |
1_150804401_G_GA | rs200891935 | Intron | 4.60E-10 C | |
1_150808889_C_G | rs2228099 | Synonymous | 6.70E-12 A | |
1_150850904_CA_C | rs10305645 | Upstream | 1.50E-11 D | |
ARSA | 22_51062832_G_A | rs8142033 | 3′UTR | 9.10E-15 A |
22_51063477_T_C | rs6151429 | 3′UTR | 3.70E-18 A | |
22_51064039_G_C | rs743616 | Missense | 6.40E-07 A | |
22_51064416_T_C | rs2071421 | Missense | 7.30E-12 A | |
CAV1 | 7_116200587_C_T | rs1049337 | 3′UTR | 2.50E-16 A |
CYP2D6 | 22_42528382_C_G | rs1080985 | Upstream | 2.40E-06 D |
CYP2R1 | 11_14900931_G_A | rs117913124 | Synonymous | 1.10E-05 D |
CYP3A5 | 7_99245914_A_G | rs15524 | 3′UTR | 2.10E-13 D |
CYP4F11 | 19_16023318_C_G | rs61175303 | 3′UTR | 3.10E-06 C |
19_16023378_G_A | rs58046343 | 3′UTR | 3.10E-06 C | |
19_16023619_T_C | rs58153611 | 3′UTR | 3.10E-06 C | |
CYP4F12 | 19_15791132_T_A | rs2074568 | Intron | 1.80E-09 A |
19_15793235_T_C | rs2285888 | Missense | 8.30E-06 A | |
19_15807884_A_G | rs593818 | Missense | 1.80E-06 A | |
EPHX2 | 8_27373923_T_C | rs4149243 | Splice_region | 2.20E-08 D |
8_27396208_G_A | rs4149253 | Synonymous | 5.80E-06 C | |
8_27401964_A_C | rs1126452 | Synonymous | 3.60E-12 D | |
8_27402074_A_G | rs1042032 | 3′UTR | 3.60E-12 D | |
8_27402132_T_C | rs1042064 | 3′UTR | 1.20E-12 D | |
FMO4 | 1_171311003_A_C | rs1042772 | 3′UTR | 1.70E-06 A |
GPX4 | 19_1106477_G_C | rs8178977 | Intron | 1.80E-09 A |
19_1106615_T_C | rs713041 | 3′UTR | 6.90E-06 A | |
GPX7 | 1_53074532_C_A | rs1047635 | 3′UTR | 2.50E-23 C |
GSR | 8_30535660_C_A | rs3594 | 3′UTR | 1.10E-15 A |
8_30536581_A_G | rs1138054 | 3′UTR | 2.90E-07 A | |
GSTM2 | 1_110210780_C_G | rs530021 | Splice_region | 6.10E-07 A |
GSTO2 | 10_106034491_A_G | rs2297235 | 5′UTR | 1.00E-12 A |
10_106037894_T_C | rs157077 | Intron | 2.40E-08 A | |
GSTZ1 | 14_77788908_G_A | rs2363643 | Intron | 1.40E-06 A |
14_77793207_G_A | rs7975 | Missense | 8.70E-06 A | |
NUDT8 | 11_67395714_C_T | rs7124513 | Synonymous | 2.50E-07 A |
PIAS2 | 18_44390536_T_C | rs17472 | 3′UTR | 3.50E-07 A |
18_44391566_T_TAG | rs149022619 | 3′UTR | 3.50E-07 A | |
PON1 | 7_94927924_C_T | rs854552 | 3′UTR | 1.20E-06 A |
7_94953895_G_A | rs705379 | Upstream | 1.90E-09 A | |
SLC22A10 | 11_63057925_G_A | rs1790218 | Stop_gained | 2.50E-21 C |
11_63064823_T_C | rs576641 | Synonymous | 5.10E-19 A | |
11_63072310_C_T | rs1201559 | Missense | 2.50E-21 C | |
11_63078986_T_C | rs1404608 | 3′UTR | 2.50E-21 C | |
11_63079101_AT_A | rs5792282 | 3′UTR | 4.40E-20 A | |
SLC29A4 | 7_5338714_T_C | rs6950111 | Synonymous | 8.20E-09 A |
7_5342413_T_C | rs11979775 | Intron | 4.10E-07 D | |
7_5342980_C_T | rs56166050 | 3′UTR | 2.80E-06 D | |
SQSTM1 | 5_179260153_C_T | rs4935 | Synonymous | 1.40E-13 A |
5_179260213_G_A | rs4797 | Synonymous | 2.80E-13 A | |
5_179264731_T_C | rs10277 | 3′UTR | 7.60E-17 A | |
5_179264915_G_T | rs1065154 | 3′UTR | 1.30E-15 A | |
SULT2A1 | 19_48374306_G_A | rs112468411 | 3′UTR | 3.50E-10 C |
19_48374320_C_T | rs112285002 | 3′UTR | 1.50E-61 C | |
19_48374538_T_C | rs296366 | 3′UTR | 1.90E-64 C | |
19_48374551_C_G | rs296365 | 3′UTR | 5.60E-21 R | |
19_48389363_G_A | rs296361 | Intron | 3.30E-34 C | |
UGT2A1 | 4_70454289_A_G | rs4148312 | 3′UTR | 5.20E-08 A |
UROC1 | 3_126200146_A_T | rs777513 | 3′UTR | 1.40E-10 A |
3_126200291_C_T | rs800950 | 3′UTR | 7.70E-07 R | |
3_126200403_A_C | rs1799398 | 3′UTR | 3.10E-12 A | |
3_126202257_G_A | rs1687477 | Synonymous | 8.50E-06 R | |
VKORC1 | 16_31102321_C_T | rs7294 | 3′UTR | 5.50E-07 A |
XRCC5 | 2_217012901_A_G | rs207906 | Synonymous | 7.60E-06 D |
aVariant identifier “chromosome _ position _ reference nucleotide _ variant nucleotide”.bGenetic model with minimal p-value: A, additive; R, recessive; D, dominant; C, codominant.