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. 2018 Dec 20;33(2):415–425. doi: 10.1038/s41375-018-0342-3

Table 2.

Clinical summary of STAT5B N642H mutant cases

Case Sex Age (y) Status (m) wcc plt Hb eos Initial diagnosis MG
E143 M 69 D (107) 16 280 100 1.5 aCML 2
E228 M 65 n/a n/a n/a n/a n/a HES 2
E492 F 7 D (13) 30 343 147 11 Myeloid sarcoma 3
E1237 M 89 D (12) 15 488 148 6 MPN-U 3
E2323 M 70 D (12) 61 107 101 10 CMML 3
E2335 M 63 D (9) 28 113 158 0.7 MDS/MPN 3
E2594 M 58 D (14) 14 128 81 4 MDS-SLD; eosinophilia at 3 years 2
E2810 M 81 D (7) 18 409 94 10 MPN-U 2
E2935 F 10 D (48) 47 157 110 27 HES 1
E3065 F 82 D (28) 25 150 100 2 CMML + MM 1
E3321 M 86 D (45) 21 n/a 152 6 HES 2
E4349 M 61 D (12) 15 16 132 5 CMML 3
E5735 M 68 D (31) 12 106 111 5 HES 3
E10926 M 70 D (16) 142 111 73 1.4 SM-AHN 2
E11076 M 72 A (68) 21 556 149 6 MDS/MPN-U 2
E11493 M 76 D (23) 42 275 92 19 MDS/MPN-U 3
E11825 F 61 A (61) 9 438 108 1.2 MDS/MPN-RS-T 2a
E11837 M 72 D (14) 11 120 156 7 MDS-MLD; eosinophilia at 3 years 1
E12398 M 77 D (15) 24 34 140 7 HES 3a
E12433 F 51 A (35) 19 151 90 3 MDS/MPN-U 2
E12601 F 64 D (14) 28 267 116 10 HES 3
E12614 F 15 A (48) 28 655 133 4 CEL-NOS 1a
E12885 F 75 D (23) 24 238 110 3 MDS/MPN 3a
E13191 M 83 A (9) 29 401 148 13 HES 3
E13206 M 85 D (4) 39 229 142 20 CEL-NOS 3
E13493 M 70 D (9) 17 195 65 6 MDS/MPN-U 3
E13661 M 42 A (60) 12 267 125 0.5 PV; eosinophilia at 25 years 3

Sex: male (M) or female (F); Age in years (y) at presentation; Status: dead (D) or alive (A) at specified number of months (m) after presentation or first detection of eosinophilia (E2594, E11837, E13661); white cell count (wcc), platelets (plt) and eosinophils (eos) ×109/L at diagnosis or first detection of eosinophilia; haemoglobin (Hb) in g/L; diagnosis: atypical chronic myeloid leukemia (aCML), hypereosinophilic syndrome (HES), myeloproliferative neoplasm, unclassifiable (MPN-U); myelodysplastic/myeloproliferative neoplasm (MDS/MPN), myelodysplastic syndrome with single lineage dysplasia (MDS-SLD), chronic myelomonocytic leukemia (CMML), multiple myeloma (MM), systemic mastocytosis with associated hematological neoplasm (SM-AHN), MDS/MPN, unclassifiable (MDS/MPN-U), MDS/MPN with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T), MDS with multilineage dysplasia (MDS-MLD), chronic eosinophilic leukemia, not otherwise specified (CEL-NOS), polycythemia vera (PV); molecular group (MG): 1 = no additional mutations; 2 = SF3B1 mutated; 3 = additional mutations but SF3B1 unmutated; not available (n/a)

aIndicates the 4 cases for whom STAT5B N642H was absent in cultured T-cells