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. 2019 Feb 6;9:1513. doi: 10.1038/s41598-018-38064-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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2B8 inhibits the ETC of mycobacterial IMVs. The ETC of mycobacterial IMVs was initiated with 130 mM succinate (a), 1 mM NADH (b) or NADH + succinate (c), and was evaluated by measuring INT reduction at 490 nm. (a) Out of the tested compounds, only 2B8 (78.12–125 µM), was able to inhibit INT reduction when the ETC was energized with succinate. (b) As expected, 80 µM TRZ inhibited INT reduction when the ETC was energized with NADH. INT reduction in the presence of NADH was also inhibited by 2B8. RA13 had a lower inhibitory effect. (c) When the ETC was activated with both NADH and succinate, 2B8 had the most potent inhibitory effect, followed by TRZ and RA13. The other tested compounds did not affect INT reduction. Experiments were repeated three separate times and representative data are shown. *p < 0.05, **p < 0.005, ***p < 0.001 by ANOVA.