Table 1.
IC50 value and selective index of eupatorin (after 24, 48 and 72 hour incubation time) and positive control doxorubicin (after 48 hour incubation time) on MCF-10a, MCF-7, and MDA-MB-231 cells.
| Cell line | IC50 value at different time point (μg/mL) | |||
|---|---|---|---|---|
| Eupatorin | Doxorubicin | |||
| 24 hr | 48 hr | 72 hr | 48 hr | |
| MCF-10a | >30 | 30.00 ± 0.01 | 30.00 ± 0.02 | 0.48 ± 0.33 |
| MCF-7 | >20 | 5.00 ± 0.01 | 3.00 ± 0.02 | 0.52 ± 0.26 |
| MDA-MB-231 | >20 | 5.00 ± 0.07 | 2.00 ± 0.05 | 0.71 ± 0.21 |
| Selective index (SI) MCF-10a/MCF-7 | — | 6 | 10 | 0.92 |
| Selective index (SI) MCF-10a/MDA-MB-231 | — | 6 | 15 | 0.68 |
Values are expressed as mean ± S.D for three independent observations.