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. 2019 Feb 6;9:1514. doi: 10.1038/s41598-018-37796-w

Table 1.

IC50 value and selective index of eupatorin (after 24, 48 and 72 hour incubation time) and positive control doxorubicin (after 48 hour incubation time) on MCF-10a, MCF-7, and MDA-MB-231 cells.

Cell line IC50 value at different time point (μg/mL)
Eupatorin Doxorubicin
24 hr 48 hr 72 hr 48 hr
MCF-10a >30 30.00 ± 0.01 30.00 ± 0.02 0.48 ± 0.33
MCF-7 >20 5.00 ± 0.01 3.00 ± 0.02 0.52 ± 0.26
MDA-MB-231 >20 5.00 ± 0.07 2.00 ± 0.05 0.71 ± 0.21
Selective index (SI) MCF-10a/MCF-7 6 10 0.92
Selective index (SI) MCF-10a/MDA-MB-231 6 15 0.68

Values are expressed as mean ± S.D for three independent observations.