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. 2019 Feb 6;9:1509. doi: 10.1038/s41598-018-36605-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Immune module analysis of TAN transcriptomes by GSEA. (A) List of enriched immune modules in TAN groups. Significant normalized enrichment scores (NES) are highlighted based on False Discovery Rates (FDR), which are shown in color as indicated by a color scale on the right. Red indicates positive values of NES and green indicates the negative values. FDR values below 0.25 are regarded as statistical significance. (B) List of leading edge genes in Module 2.1 Cytotoxicity. Gene No. 1–14 are common among all the TAN groups. No. 15 is common in TAN_L and TAN_M. No. 16–18 are only found in TAN_L. The bold highlighted genes are discussed in the paragraph. N.A., not available.