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. 2019 Feb 6;9:1509. doi: 10.1038/s41598-018-36605-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Enrichment of TAN signatures in comparison to mouse TAN dataset. (A–F) Enrichment plots by GSEA in comparison of zebrafish TANs with mouse TAN (A–C) or G-MDSC (D–F). Up-regulated genes from TAN_L (A,D), TAN_M (B,E), and TAN_F (C,F) as signatures were compared to a mouse TAN microarray dataset (GSE43254) by GSEA. The similarity between zebrafish TAN groups and mouse TAN (TAN_mus) was separately compared against mouse NN (NN_mus, A–C) and against mouse G-MDSC (G-MDSC_mus, D–F). NES indicate the correlation between two dataset and a positive value refers to positive correlation. FDR measures the statistical significance of NES, and the value below 0.25 is regarded as significance. (G) List of the top 10 leading edge genes between zebrafish TAN groups and TAN_mus basedon mouse gene symbols. The leading edge genes which also emerged in other TAN groups are labeled in red.