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. 2019 Feb 6;10:616. doi: 10.1038/s41467-018-08202-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Robust donor-specific tolerance after CD117-ADC conditioning and fully MHC-mismatched sequential bone marrow and skin allotransplantation. C57Bl/6 animals were conditioned as indicated at the top of each panel, then transplanted with 2 × 10⁷ total BM cells, followed by skin allotransplantation, according to the protocol shown in Fig. 1a. a Representative example of skin allograft outcome 336 (primary) and 265 (secondary) days post skin transplantation. BM donor-type (BALB/c) and third-party (CBA/Ca) skin allografts were transplanted at 168 (primary) and 239 (secondary) days post BMT preceded by conditioning with isotype control antibody (left) or CD117-ADC (right). Circles locate the site of skin transplantation: solid lines, rejected transplants; dotted lines, viable transplants. Arrows demarcate the margin of the surviving skin allograft. b Skin allograft survival curves summarized from two independent experiments comparing conditioning regimens. The survival was analyzed by the following tests: Log-rank (Mantel-Cox) test (χ2 65.88), Log-rank test for trend (χ2 25.75), and Gehan-Breslow-Wilcoxon test (χ2 56.36)