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. 2019 Feb 6;5:62. doi: 10.1038/s41420-018-0134-6

Fig. 1. Decreased NAMPT expression attenuates inflammation and bone erosion in collagen-induced arthritis.

Fig. 1

CIA was induced in 8 weeks old, male DBA/1J Nampt+/+ and Nampt+/− mice. Observable inflammation was observed for 10 weeks. Serum and hind limbs were collected for ELISA and micro-CT analysis, respectively. a Changes in joint inflammation scores in Nampt+/+ (n = 11) and Nampt+/− (n = 13). Arthritic index score is reported as mean ± median absolute deviation. b Serum concentrations of anti-collagen antibody (scale ×100,000) and NAMPT. The results are presented as mean ± SD; Nampt+/+ CIA (n = 3), Nampt+/− CIA (n = 5). c Representative micro-CT images of left hind paws and talus bones. Arrow represents the location of the talus in ankle joint. d Bone volume (BV) and bone volume per total volume (BV/TV) in talus are presented as mean ± SD; Nampt+/+ (n = 5), Nampt+/− (n = 4), Nampt+/+ CIA (n = 6), 7 Nampt+/− CIA (n = 6). *P < 0.05, **P < 0.005