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. 2019 Feb 6;9:1502. doi: 10.1038/s41598-018-37846-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Surface expression of memory markers CD27 and CD45RO on CD4⁺ T-lymphocytes from TB-HIV co-infected patients prior to and following ART initiation. Frequencies of CD27⁺CD45RO⁻ (naïve), CD27⁺CD45RO⁺ (central memory), CD27⁻ CD45RO⁻ (effector) and CD27⁻CD45RO⁺ (effector memory) CD4⁺ T cells from whole blood obtained at week 0 (pre-ART) and at week 6 after ART initiation (in non-IRIS patients, n = 22) or at the time of TB-IRIS event (n = 26). Lines represent median values and interquartile ranges. Data were analyzed using the Mann-Whitney test or Wilcoxon matched-pairs test for paired analyses within each study group. **P < 0.01 after adjustment for multiple measurements.