Table 2.
K | N | RR [95% CI] | P | Study heterogeneity | P (between-group comparison) | ||||
---|---|---|---|---|---|---|---|---|---|
Chi2 | df | I2 (%) | P | ||||||
Duration of treatment | 0.40 | ||||||||
≤ 3 days | 14 | 1027 | 0.58 [0.48, 0.69] | < 0.001 | 13.75 | 13 | 5 | 0.39 | |
> 3 days | 3 | 453 | 0.66 [0.47, 0.81] | < 0.001 | 2.33 | 3 | 0 | 0.51 | |
Daily dose | 0.14 | ||||||||
Low (≤ 0.25 g/kg) | 10 | 685 | 0.52 [0.42, 0.65] | < 0.001 | 5.12 | 9 | 0 | 0.82 | |
High (> 0.25 g/kg) | 5 | 606 | 0.68 [0.55, 0.85] | < 0.001 | 7.06 | 4 | 29 | 0.22 | |
Total dose | 0.03 | ||||||||
Low (< 0.9 g/kg) | 11 | 740 | 0.50 [0.40, 0.62] | < 0.001 | 7.39 | 10 | 0 | 0.69 | |
High (≥ 0.9 g/kg) | 5 | 551 | 0.70 [0.56, 0.87] | 0.002 | 3.80 | 4 | 0 | 0.43 | |
Type of control intervention | 0.14 | ||||||||
Placebo | 14 | 1141 | 0.57 [0.48, 0.67] | < 0.001 | 11.26 | 13 | 0 | 0.59 | |
Human albumin solution | 5 | 389 | 0.74 [0.54, 1.01] | 0.05 | 1.56 | 4 | 0 | 0.45 | |
Follow-up duration | 0.21 | ||||||||
≤ 28 days | 11 | 1135 | 0.64 [0.54, 0.76] | < 0.001 | 10.14 | 10 | 1 | 0.43 | |
> 28 days | 3 | 158 | 0.35 [0.17, 0.71] | 0.004 | 3.42 | 2 | 42 | 0.18 | |
ICU days | 5 | 237 | 0.56 [0.40, 0.77] | < 0.001 | 1.87 | 4 | 0 | 0.76 | |
Study design | 0.27 | ||||||||
Randomized controlled trial | 15 | 978 | 0.65 [0.53, 0.78] | < 0.001 | 10.72 | 14 | 0 | 0.71 | |
Cohort study | 4 | 552 | 0.35 [0.25, 0.50] | < 0.001 | 4.80 | 3 | 37 | 0.19 | |
Publication year | 0.21 | ||||||||
Old studies (before 2005) | 10 | 485 | 0.52 [0.40, 0.68] | < 0.001 | 6.38 | 9 | 0 | 0.70 | |
Recent studies (from 2005) | 9 | 1045 | 0.64 [0.54, 0.76] | < 0.001 | 10.05 | 8 | 20 | 0.26 |
K number of studies, N number of participants, ICU intensive care unit, RR relative risk, CI confidence interval