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. 2019 Feb 6;9:27. doi: 10.1186/s13613-019-0501-3

Table 2.

Results of subgroup analysis based on different standards

K N RR [95% CI] P Study heterogeneity P (between-group comparison)
Chi2 df I2 (%) P
Duration of treatment 0.40
  ≤ 3 days 14 1027 0.58 [0.48, 0.69] < 0.001 13.75 13 5 0.39
  > 3 days 3 453 0.66 [0.47, 0.81] < 0.001 2.33 3 0 0.51
Daily dose 0.14
 Low (≤ 0.25 g/kg) 10 685 0.52 [0.42, 0.65] < 0.001 5.12 9 0 0.82
 High (> 0.25 g/kg) 5 606 0.68 [0.55, 0.85] < 0.001 7.06 4 29 0.22
Total dose 0.03
 Low (< 0.9 g/kg) 11 740 0.50 [0.40, 0.62] < 0.001 7.39 10 0 0.69
 High (≥ 0.9 g/kg) 5 551 0.70 [0.56, 0.87] 0.002 3.80 4 0 0.43
Type of control intervention 0.14
  Placebo 14 1141 0.57 [0.48, 0.67] < 0.001 11.26 13 0 0.59
Human albumin solution 5 389 0.74 [0.54, 1.01] 0.05 1.56 4 0 0.45
Follow-up duration 0.21
  ≤ 28 days 11 1135 0.64 [0.54, 0.76] < 0.001 10.14 10 1 0.43
  > 28 days 3 158 0.35 [0.17, 0.71] 0.004 3.42 2 42 0.18
 ICU days 5 237 0.56 [0.40, 0.77] < 0.001 1.87 4 0 0.76
Study design 0.27
 Randomized controlled trial 15 978 0.65 [0.53, 0.78] < 0.001 10.72 14 0 0.71
Cohort study 4 552 0.35 [0.25, 0.50] < 0.001 4.80 3 37 0.19
Publication year 0.21
 Old studies (before 2005) 10 485 0.52 [0.40, 0.68] < 0.001 6.38 9 0 0.70
 Recent studies (from 2005) 9 1045 0.64 [0.54, 0.76] < 0.001 10.05 8 20 0.26

K number of studies, N number of participants, ICU intensive care unit, RR relative risk, CI confidence interval