Table 4. Effects of high and low sugars diets on lipoprotein kinetics and DNL.
| NAFLD (n = 11) | Controls (n = 14) | |||
|---|---|---|---|---|
| High sugars | Low sugars | High sugars | Low sugars | |
| VLDL1-TAG production rate (g/day) | 20.9 ± 2.1 | 18.9 ± 2.12 | 16.6 ± 1.4 | 12.4 ± 1.23 |
| VLDL1-TAG FCR (pools/day)1 | 9.0 ± 0.92 | 9.5 ± 1.0 | 11.3 ± 0.7 | 11.9 ± 0.8 |
| VLDL2-TAG production rate (g/day) | 4.90 ± 0.59 | 3.70 ± 0.434 | 3.63 ± 0.27 | 3.98 ± 0.43 |
| VLDL2-TAG FCR (pools/day) | 11.5 ± 1.1 | 12.2 ± 1.3 | 13.1 ± 1.0 | 14.3 ± 0.9 |
| VLDL1-apoB production rate (mg/day) | 481 ± 76 | 492 ± 58 | 546 ± 56 | 414 ± 54 |
| VLDL1-apoB FCR (pools/day) | 9.0 ± 1.0 | 10.8 ± 2.2 | 14.7 ± 2.7 | 13.4 ± 2.4 |
| VLDL2-apoB production rate (mg/day) | 546 ± 176 | 498 ± 164 | 720 ± 310 | 647 ± 212 |
| VLDL2-apoB FCR (pools/day) | 12.5 ± 2.8 | 12.8 ± 2.4 | 13.6 ± 1.9 | 14.9 ± 1.6 |
| IDL-apoB production rate (mg/day) | 609 ± 122 | 391 ± 695 | 740 ± 159 | 737 ± 213 |
| IDL-apoB FCR (pools/day) | 9.5 ± 1.9 | 8.7 ± 0.9 | 12.2 ± 1.1 | 12.1 ± 1.2 |
| LDL2-apoB production rate (mg/day) | 1452 ± 277 | 858 ± 101 | 1075 ± 109 | 1176 ± 118 |
| LDL2-apoB FCR (pools/day) | 1.59 ± 0.25 | 1.35 ± 0.23 | 1.59 ± 0.24 | 1.74 ± 0.26 |
| LDL3-apoB production rate (mg/day) | 2069 ± 388 | 942 ± 278 | 1518 ± 237 | 1374 ± 273 |
| LDL3-apoB FCR (pools/day) | 1.01 ± 0.15 | 0.46 ± 0.096 | 0.86 ± 0.12 | 1.06 ± 0.24 |
| Contribution of DNL to: | 1.66 ± 0.39 | 1.59 ± 0.343 | 1.32 ± 0.43 | 0.56 ± 0.147 |
| VLDL1-TAG production (g/day) | 1.66 ± 0.39 | 1.59 ± 0.347 | 1.32 ± 0.43 | 0.56 ± 0.14 |
| VLDL2-TAG production (g/day) | 0.28 ± 0.05 | 0.29 ± 0.05 | 0.26 ± 0.05 | 0.19 ± 0.03 |
1Analysed for first period only, so between group comparisons (within diet) only were analysed (NAFLD; high sugar n = 7, low sugar n = 4. Controls; high sugar n = 7, low sugar n = 7). Values are mean ± SEM. Significant differences between groups (within diet) 2P = 0.01; 6P<0.05; 7P = 0.003. Significant differences between diets (within group) 3P = 0.02; 4P = 0.036; 5P = 0.06. All differences were adjusted for body weight. For the IDL and LDL2 kinetic data NAFLD (n = 9), and n = 8 for the LDL3 kinetic data due to insufficient data for the model fit.