Table 2. Top regulated canonical pathways and upstream regulators from Ingenuity analysis of the genes differentially expressed between female WT and KCNJ5 KO (−/−) adrenals.
| Canonical pathway name | P-value | Overlap |
|---|---|---|
| FXR/RXR activation | 1.58 × 10−10 | 11.7% 16/137 |
| L×R/R×R activation | 5.69 × 10−10 | 11.7% 15/128 |
| TR/R×R activation | 4.11 × 10−9 | 12.4% 13/105 |
| Retinol biosynthesis | 3.11 × 10−8 | 18.4% 9/49 |
| Acute phase response signalling | 2.13 × 10−7 | 8.2% 14/171 |
| Upstream regulator | P-value of overlap | Predicted activation |
| TO-901317 (L×R agonist) | 1.66 × 10−36 | Down in KO |
| PPARα | 2.89 × 10−36 | Down in KO |
| PPARγ | 1.15 × 10−35 | Down in KO |
| Rosiglitazone (PPARG agonist) | 3.16 × 10−33 | Down in KO |
| BSCL2 | 7.87 × 10−29 | - |
Ranked by P-value.