Figure 5. Global PTP1B inhibition reduces serum total cholesterol and triglycerides and prevents atherosclerotic plaque development.

Blood was collected at terminal culls and serum analysed for circulating total cholesterol (A) triglyceride levels (B) using ELISA (Sigma). (C) Representative (n=5–6 per group) aortic root sections of HFD-fed mice stained with Oil Red O. (D) Quantification of plaque area as analysed using ImageJ software. Data are represented as mean ± S.E.M. and analysed by unpaired two-tailed ttests where *P≤0.05 or **P≤0.01 when compared with saline control.