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Abnormal capillary topology in the sickle cell compared to control mice. (a) The Euclidean between branch points, an indication of the degree of vessel tortuosity, was significantly shorter in sickle cell mice (p < 0.0001, Mann–Whitney test). (b) Sickle cell mice also have significantly shorter capillary branch length compared to controls (p = 0.0065, Mann–Whitney U-test). Error bars represent mean ± SD, 1 − β = 0.99 in (a) and 0.99 in (b).
