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. 2019 Feb 6;9:1530. doi: 10.1038/s41598-018-38383-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of DOSS treatment on body mass and body composition in male and female F1 mice. Body mass was measured at 12 and 16 weeks of age (males, n = 28 treatment, 30 control; females, n = 16/group). At 12 weeks of age, DXA scans were used to assess body composition in male and female mice. Measurements were obtained for (A) male body mass, (B) female body mass, (C) percent fat, (D) fat mass, (E) lean mass, and (F) bone area, (E) bone mineral density, and (F) bone mineral content, (C) male adipose tissue mass, (D) female adipose tissue mass, (E) male adipose tissue percent, (F) female adipose tissue percent. Graph bars represent means and standard deviations. Male and Female mice were analyzed separately using unpaired t-test (*p < 0.05).