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. 2019 Feb 6;9:1530. doi: 10.1038/s41598-018-38383-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Developmental DOSS treatment alters circulating levels of leptin in male F1 mice. At time of sacrifice (16 weeks), plasma and adipose tissue was collected (n = 12/group). Circulating levels of leptin were determined using MSD assays. Gene expression was determined via RNA isolation, cDNA conversion and qPCR using the delta delta Ct method with Hprt as the housekeeping gene. Results are shown for (A) normalized circulating levels of leptin, (B) leptin correlated with fat mass, and (C) leptin gene expression in IWAT (n = 12/group). Graph bars represent means and standard deviations. Linear regression was used to determine correlations between adiponectin and leptin and fat mass (*p < 0.05 unpaired t-test).