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. 2019 Jan 31;10:45. doi: 10.3389/fimmu.2019.00045

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Copyright © 2019 Yang, Ho, Cowell, Jilani, Foster and Prince.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Altered pathogenicity of mutants in zebrafish models of in vivo infection. Zebrafish embryos at 24 hpf were injected into the circulation valley with JE2, lspA, purB, or clpP mutants (A,B) transductants. Exact inoculum was determined retrospectively by Miles Misra assays and indicated as subscript values. (C) At 30 min post-fertilization zebrafish embryos were injected with a pu.1 morpholino to delete phagocytes. Embryos were injected at 32 hpf into the circulation valley with the indicated inoculum of JE2, lspA, purB, or clpP strains. Survival curves over 92 h post-infection (hpi) were calculated by Kaplan-Meier analysis, statistical significance is indicated by ^**p < 0.01, ^***p < 0.001.