Table IV.
Results of differential expression analysis after dividing the samples into groups according to different clinical factors.
| Clinical factors | Downregulated genes | Upregulated genes |
|---|---|---|
| Age in years (above vs. below median) | WBSCR26, TRIM54, ARX, SERPINA4, MT1H, AQP5, PRSS21, MSLN, APOBEC1, CALHM3 | NTSR1, SPRR3, KLK10, SPRR1A, ALDH3A1, SERPINB3, CXCL17, SPRR1B, KLK1, SYCN, TRY6, CELA2B, PNLIPRP2, CLPS, CELA3A, REG1A, CELA3B, PNLIP, CELA2A |
| Sex (male vs. female) | NLRP2 | HOXA13, UPK1B |
| Chronic pancreatitis history | PNLIP, PNLIPRP1, CPA1, CELA2A, CLPS, CELA2B, TRY6, | PLEKHN1, POU2F3, CATSPER1, ABCA12, GPR110, WBSCR26, UGT1A6, |
| (yes vs. no) | REG3G, CELA3B, SYCN, TDRD9, ARX, KCNJ3, KIAA1409, ST18, TMEM132D, KCNMB2, SYT4 | HOXB9, MYEOV, S100P, GJB5, GJB4, GJB3, SFTPA2, NMU |
| Diabetes history (yes vs. no) | ABCA13 | NMUR2 |
| Alcohol (yes vs. no) | S100A2 | C5orf49 |
| Tobacco (never vs. reform) | – | – |
| Tobacco (never vs. current) | PPP1R1A, CRYBA2, SEZ6L, RIMBP2, LHFPL4, VWA5B2, PCSK1N, HMGCLL1, GRM4, ARX, TMEM63C, ASTN1, TCEAL2, LRRC10B, SSTR2, DUSP26, C1QL1, GCK, SNAP91, CACNA1A, JPH3, MSI1 | GPR110, DKK1, MUC4, SERPINB4, SERPINB3, MUC16 |
| Pathologic_M (M0 vs. M1) | – | – |
| Pathologic_T (T1+ T2 vs. T3+T4) | SYT4GPR98, SPTBN4, CELF4, ASTN1, CHD5, UNC13A, HAP1, HMGCLL1, FBLL1, PTPRT, LRRC24, ATP1A3, APOH, MSI1, PIPOX, LRRC4B, HPCA, | KPNA7, HOXA13, DSG3, UPK1B, AKR1B10 |
| Pathologic_N (N0 vs. N1) | LOC389332, GRM4, LRRC16B | MMP3, AIM2, HOXA13, ABCA13, CXCL11, EGF, GJB4, PIK3C2G, AKR1B10, ITGB6, C12orf36, KRT5, NMUR2, SERPINA4, UPK1B, GABRP, CXCL5, REG3G, CTRC, PNLIPRP1 |
| Radiation therapy (yes vs. no) | LOC554202, TNS4 | AIM2 |
| Targeted molecular therapy (yes vs. no) | ZNF683, KPNA7, RASEF, MT1H, GPR110, SERPINA4, EGF, UPK1B, KLK1, TRY6, CELA2B, SYCN | PNLIPRP2, PNLIPRP1, REG1A, CLPS, REG3G, CELA3B, CELA2A, REG1B, PNLIP, CTRC, CPA1, CELA3A, CTRB2 |
| New tumor (yes vs. no) | LOC389332, LRRC16B, FFAR2, PIPOX, RAB3C, JPH3 | CDSN, PLEKHN1, ABCA13, WBSCR26, TMEM105, GPR1, FAM83B, GJB4, CYP27C1, GJB5, LOC554202, FGFBP1, ABCA12 |
Tobacco: current, subjects who smoke at least once a month; reform, those who have tried smoking but have quit; never, those who have never tried tobacco). Pathologic_M: M0, no distant metastasis; M1, distant metastasis. Pathologic_T: T1, unilateral tumor 80 cm2 or less in area; T2, unilateral tumor more than 80 cm2 in area; T3, unilateral tumor rupture before treatment; T4, bilateral tumors. Pathologic_N: N0, no regional lymph node metastasis; N1, regional lymph node metastasis. New tumor, tumor metastasis or spread to other parts of the body.