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. 2019 Jan 11;41(3):1678–1690. doi: 10.3892/or.2019.6968

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Inhibition of the phosphatidylinositol 3-kinase/AKT serine/threonine kinase pathway reduces the proportion of SP cells in NCI-H929 and NCI-H929/ABCG2⁺ cell lines. ABCG2 (A) mRNA and (B) protein expression levels were markedly higher in NCI-H929/ABCG2⁺ cells compared with control cells (NCI-H929/NC) and uninfected NCI-H929 cells (NCI-H929). (C) Representative flow cytometry plots of SP cells before and after treatment with 20 µM LY294002 or 100 nM rapamycin in NCI-H929 and NCI-H929/ABCG2⁺ cell lines. (D) Proportion of SP cells was significantly higher in the NCI-H929/ABCG2⁺ cell line compared with in the NCI-H929 cell line. n=3 tests/group. **P<0.01. ABC, ATP binding cassette; ABCG2, ABC subfamily G member 2; NC, negative control.