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. 2019 Jan 11;41(3):1678–1690. doi: 10.3892/or.2019.6968

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Inhibition of the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway in NCI-H929 cells enhances their sensitivity to chemotherapeutic drugs. (A and B) Cell death rate was significantly lower in NCI-H929/ABCG2⁺ cells compared with NCI-H929 cells treated with (A) As₂O₃ or (B) Bort. (C and D) LY or RA treatment significantly increased cell death rate in regular and ABCG2-overexpressing NCI-H929 cells following treatment with various doses of (C) As₂O₃ or (D) Bort. **P<0.01. ABC, ATP binding cassette; ABCG2, ABC subfamily G member 2; As₂O₃, arsenic trioxide; Bort, bortezomib; LY, LY294002; RA, rapamycin.