Figure 5.
SHCBP1 enhances the invasion and metastasis of GC cells. (A and C) Wound healing assay revealed the mobility of MGC-803 and SGC-7901 cells after sh-SHCBP1 knockdown, with sh-NC used as a control. (B and D) Percentage statistics of wound healing in A and C. ***P<0.001. (E) Transwell assays examined the effect of SHCBP1 knockdown on cell migration (top panel) and invasion (bottom panel). (F) Statistical graph of the number of migrated and invaded cells. **P<0.01, ***P<0.001. SHCBP1, SHC SH2 domain-binding protein 1; GC, gastric cancer; sh-SHCBP1, SHCBP1-shRNA; sh-NC, negative control-shRNA.