Figure 3. Polio virus receptor (PVR) copy number segments log2 (tumor/normal, mean + SEM) according to microsatellite instability (MSI) incolorectal cancer as a dichotomized variable (A) and as class (B). Note that in A, lack of MSI (82 tumors) was associated with significantly increasedPVR copy number segments compared to microsatellite instability (11 tumors). In B, MSI-low (100 tumors) status was associated with significantlyincreased PVR copy number segments compared to MS-stable (25 tumors) and MSI-high (25 tumors) status (p=0.005). Tukey’s post hoc test showedthat PVR copy number segments for those with MSI-high/MS-stable status were both significantly different from those with MSI-low status (p=0.01).PVR copy number segments for those with MSI-high and MS-stable colorectal cancer were not significantly different from one another (p=0.76).