Table 4.
KEGG pathways classification of differentially expressed proteins.
| DEPs | Pathway description | Protein count | Matching proteins |
|---|---|---|---|
| Upregulated DEPs | Cytokine–cytokine receptor interaction | 11 | CCL7, CCR1, CCR2, EDA, FASLG, HGF, IFNB1, IL17B, IL24, IL26, MPL |
| PI3K-Akt signaling pathway | 7 | FASLG, FGF8, HGF, IFNB1, NGF, PGF, VWF | |
| Proteoglycans in cancer | 6 | CTNNB1, DCN, ERBB4, FASLG, FGF8, HGF | |
| Rap1 signaling pathway | 5 | CTNNB1, FGF8, HGF, NGF, PGF | |
| Ras signaling pathway | 5 | FASLG, FGF8, HGF, NGF, PGF | |
| Jak-STAT signaling pathway | 4 | IFNB1, IL24, IL26, MPL | |
| Downregulated DEPs | Pathways in cancer | 6 | FGF16, FGF18, ITGA2B, KITLG, MMP9, SMAD4 |
| Cytokine–cytokine receptor interaction | 5 | CCL1, CCR7, CNTF, EPO, KITLG | |
| Hematopoietic cell lineage | 4 | EPO, ITGA2B, KITLG, TFRC | |
| Notch signaling pathway | 3 | ADAM17, DLL1, MFNG | |