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. 2019 Jan 31;7:6. doi: 10.3389/fcell.2019.00006

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Copyright © 2019 Mattioli, Andrenacci, Mai, Valente, Robijns, De Vos, Capanni and Lattanzi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Modulation of lamin A/C-HDAC2 interaction by statins. (A) Co-immunoprecipitation of lamin A/C and HDAC2 in the presence or absence of mevinolin as indicated in the legend. A representative western blot is shown. Molecular weight markers are indicated in kDa. Densitometric analysis of immunoprecipitated HDAC2 bands is reported in the graph. Statistical significance (p < 0.01) is indicated. (B) PLA of lamin A/C and HDAC2 or prelamin A and HDAC2 in human dermal fibroblasts left untreated (NT) or treated with mevinolin (Mevinolin). Nuclei are counterstained with DAPI. Quantitative analysis of PLA signals (red dots) is reported in the graphs. Statistical significance (p < 0.05) is indicated.