Table I.
Clinical information of patients with colorectal cancer.
| Genotype | |||
|---|---|---|---|
| Factors | AA (n=88) | AG (n=17) | P-value |
| Sex | 0.04a | ||
| Male | 62 | 16 | |
| Female | 26 | 1 | |
| Median age, years | 66 | 60 | 0.08 |
| Primary site | 0.27 | ||
| Colon | 49 | 7 | |
| Rectum | 39 | 10 | |
| Stageb | 0.63 | ||
| II | 10 | 1 | |
| III | 28 | 7 | |
| IV | 50 | 9 | |
| Number of cycles of CDDP treatment | 0.05 | ||
| Adj | 3 | 1 | |
| 1st | 49 | 3 | |
| 2nd | 26 | 11 | |
| Following 3rd | 10 | 2 | |
| Cycle (median) | 10 | 10 | 0.81 |
| Timeframe | 0.63 | ||
| Synchronous | 47 | 8 | |
| Metachronous | 41 | 9 | |
| Cancellation reason | 0.61 | ||
| PD | 35 | 4 | |
| Toxicity with PN | 25 | 7 | |
| Toxicity without PN | 18 | 4 | |
| Other | 10 | 2 | |
a
P<0.05.
b
Staging according to the International Union Against Cancer Tumor-Node-Metastasis classification 8th edition (39). Adj, adjuvant chemotherapy; PD, progressive disease; PN, peripheral neuropathy.